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KMID : 0382619930130020599
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Hanyang Journal of Medicine
1993 Volume.13 No. 2 p.599 ~ p.610
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Expression of p53 Gene in Human Primary Lung Cancers
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이영규
박성수/신동호/이동후/이정희/이중달
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Abstract
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The cell cycle is composed of a series of steps which can be negatively or positively regulated by various factors. Alteration or inactivation of p53 by mutations, or by its interactions with oncogene products of DNA tumor viruses, can lead to
cancer.
Mutations of the p53 gene occur frequently in human primary lung cancers and the wild-type p53 allele is often concomitantly deleted. These suggest that deprivation of suppressive role of the wile-type p53 may ensure tumor cell growth presumably
y
the
mutant p53 gene.
In an attempt to investigate this hypothesis, a mutant p53 gene was immunohistochemically demonstrated in the formalin-fixed paraffin-embedded tissue sections of lung cancers by using a monoclonal antibody p53 (Ab-3 and clone DO7). The expression
of
p53(DO7) was found in all of four normal lung tissues, four small cell carcinomas, and four non small cell carcinomas in histologic type of lung cancer. In the six normal lung tissues the expressions of p53 (Ab-3) were not found. Contrarily. The
expression of p53 (Ab-3) was found in the nuclei of lung cancers among fifteen(46.9%) of thirty-two cases studies. The expression of p53(Ab-3) was disclosed in three cases (37.5%) of eight small cell carcinomas and twelve cases(50.0%) of
twenty-four non
small cell carcinomas in histologic type of lung cancer.
These findings suggest that expression of the mutant p53 is related to the one of events in the pathogenesis of human lung cancer and the role of the other oncogenes might be also related to the development of lung cancer.
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KEYWORD
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